Chapter 6 - Additional Information


You’re watching Additional Information, chapter six of the genetics and fertility video series from the American Society for Reproductive Medicine.  

Transferring embryos that test normal may help lower the chance of miscarriage, but the risk is never zero.

But, it can also be stressful when you have a transfer of an embryo that tested normal and it doesn’t result in a pregnancy. IVF success can be affected by many other things that we don’t yet understand.


For some families, another option is to conceive naturally, understanding the chance of having an affected child.

For example, if both parents have an autosomal recessive single-gene defect for cystic fibrosis, you would have:
  • a 1 in 4 chance to have a child with CF, and
  • a 3 in 4 chance of having a healthy child.
Of those 3 healthy children, there is: 
  • a 1 in 3 chance of a healthy child without the trait, and
  • a 2 in 3 chance of having a child who is healthy but carries the trait like you do.
Another option, especially for those who are carriers of a single-gene defect, is to use donor egg or donor sperm in place of your egg or sperm.  The donor of the egg or sperm would be tested for CF, so the chances of having a child with CF would be minimal, though you could end up with children who are carriers. You will need to think about whether having a genetic link to your child is important to you.

Some couples who do not want the invasiveness or expense of IVF and PGT could consider Intrauterine insemination–IUI also called artificial insemination. IUI is a medical procedure where prepared semen is injected into the biological mother’s uterus resulting in fertilization of her eggs. This is a less expensive, less invasive option.

We hope you found this information helpful. For more information about genetic testing in the setting of infertility treatment, visit
is a patient education website of ASRM.